09:00 - 09:30
Breakfast
Evolutionary and functional perspective on human polygenic traits
10:30 - 10:45
Coffee Break
11:00 - 11:20
Improved imputation of rare genetic variants using deep learning [Paper Talk]
Ulzee An, Jingyuan Fu, Eleazar Eskin and Sriram Sankararaman
11:20 - 11:40
Polygenic scoring accuracy varies across the genetic ancestry continuum [Highlight Talk]
Yi Ding, Kangcheng Hou, Ziqi Xu, Aditya Pimplaskar, Ella Petter, Kristin Boulier, Florian Privé, Bjarni J. Vilhjálmsson, Loes M. Olde Loohuis and Bogdan Pasaniuc
11:40 - 12:00
Power of inclusion: Enhancing polygenic prediction with admixed individuals [Highlight Talk]
Yosuke Tanigawa and Manolis Kellis
12:00 - 12:15
Extending Genome-Wide Association Studies to admixed cohorts with high degrees of relatedness [Poster Talk]
Taotao Tan, José Martínez-Magaña, Janitza Montalvo-Ortiz, Wei Zhou and Elizabeth Atkinson
12:15 - 12:30
PhenoEncoder: A Multi-Autoencoder Approach for Disease-Aware Compression of Genomic Data [Poster Talk]
Gizem Taş, Jan Herman Veldink, Alexander Schoenhuth and Marleen Balvert
12:30 - 13:30
Lunch Break (Lunch Provided)
13:30 - 13:50
COX proportional hazards Mixed Model (COXMM) accurately estimates the heritability of time-to-event traits [Paper Talk]
Kodi Taraszka and Alexander Gusev
13:50 - 14:10
dotears: Scalable, consistent DAG estimation using observational and interventional data [Paper Talk]
Albert Xue, Jingyou Rao, Sriram Sankararaman and Harold Pimentel
14:10 - 14:30
Deep Learning-based Phenotype Imputation on Population-scale Biobank Data Increases Genetic Discoveries [Highlight Talk]
Ulzee An, Ali Pazokitoroudi, Marcus Alvarez, Lianyun Huang, Silviu Bacanu, Andrew J. Schork, Kenneth Kendler, Päivi Pajukanta, Jonathan Flint, Noah Zaitlen, Na Cai, Andy Dahl and Sriram Sankararaman
14:30 - 14:50
Impact of cross-ancestry genetic architecture on GWASs in admixed populations [Highlight Talk]
Rachel Mester, Kangcheng Hou, Yi Ding, Gillian Meeks, Kathryn S Burch, Arjun Bhattacharya, Brenna M Henn and Bogdan Pasaniuc
14:50 - 15:05
Multimodal analysis of RNA sequencing data powers discovery of complex trait genetics [Poster Talk]
Daniel Munro, Nava Ehsan, Robert Vogel, Mehdi Esmaeili-Fard, Alexander Gusev, Abraham Palmer and Pejman Mohammadi
15:05 - 15:20
Leveraging data from diverse ancestries to uncover comprehensive genotype driven fetal- and adult-specific brain transcriptomic mechanisms in psychiatric disorders [Poster Talk]
Aarti Jajoo, C Chatzinakos, A Aruldass, C Wen, T Bigdeli, M Gandal and N Daskalakis
15:30 - 16:30
Poster Session & Coffee Break
16:30 - 16:50
Exploring Nonlinear Dimensionality Reduction Techniques for Population Structure Inference from Genotypes [Paper Talk]
Varuni Sarwal, Boyang Fu and Sriram Sankararaman
16:50 - 17:10
Ultra-fast variant effect prediction using biophysical transcription factor binding models [Paper Talk]
Maria Chikina, Ali Tugrul Balci, Dennis Kostka and Rezwan Hosseini
17:10 - 17:30
Fast kernel-based association testing of non-linear genetic effects for biobank-scale data [Highlight Talk]
Boyang Fu, Ali Pazokitoroudi, Mukund Sudarshan, Zhengtong Liu, Lakshminarayanan Subramanian and Sriram Sankararaman
17:30 - 17:45
High-resolution detection of copy number alterations in single cells with SCANNER [Poster Talk]
Yifan Zhao, Lovelace J. Luquette, Xiaochen Wang, Ruibin Xi, Alex D. Veit, Vinayak V. Viswanadham, Mark D. Johnson, Hong Wei Yang, Diane S. Shao, Christopher A. Walsh and Peter J. Park
17:45 - 18:00
The presence of cryptic relatedness creates inflation in meta-analyses of genome-wide association studies [Poster Talk]
Tiffany Tu and Alejandro Ochoa