| 8:30-9:25 AM |
Breakfast and registration |
|
| 9:25-9:30 AM |
Opening remarks |
|
| 9:30-10:30 AM |
Keynote: Finding Mechanism of Resistance in Cancer |
Gad Getz |
| 10:30-10:45 AM |
Coffee break |
|
| 10:45-11:05 AM |
Orchard: building large cancer phylogenies using stochastic combinatorial search (paper) |
Ethan Kulman, Rui Kuang and Quaid Morris |
| 11:05-11:25 AM |
A regression based approach to phylogenetic reconstruction from multi-sample bulk DNA sequencing of tumors (paper) |
Henri Schmidt and Benjamin Raphael |
| 11:25-11:45 AM |
Sc-TUSV-ext: Single-cell clonal lineage inference from single nucleotide variants (SNV), copy number alterations (CNA) and structural variants (SV) (paper) |
Nishat Anjum Bristy, Xuecong Fu and Russell Schwartz |
| 11:45-12:05 PM |
Accurate integration of single-cell DNA and RNA for analyzing intratumor heterogeneity using MaCroDNA (highlight) |
Mohammadamin Edrisi, Xiru Huang, Huw Alexander Ogilvie and Luay Nakhleh |
| 12:05-1:30 PM |
Lunch |
|
| 1:30-2:30 PM |
Keynote: A new mechanism for oncogene amplification |
Peter Park |
| 2:30-3:00 PM |
Lightning talks:
- Ahmad et al. Haplotype-specific karyotypes reconstruction and copy number aberrations/profiling from long reads sequencing data
- Ostroverkhova et al. Elucidating rare driver mutations in human cancer
- Ma et al. Spatial landscape of malignant pleural and peritoneal mesothelioma tumor immune microenvironment
- Vahid et al. Elucidating transcriptional tumor plasticity in pancreatic adenocarcinoma using pooled single cell RNA CRISPR screens
- Geuenich et al. Identifying HLA mediated antigen presentation deficiency at single cell resolution using transfer learning
- Stöber et al. Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity
|
|
| 3:00-4:30 PM |
Poster session & coffee break |
|
| 4:30-4:50 PM |
Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment (highlight) |
Marcos Díaz-Gay, Raviteja Vangara, Mark Barnes, Xi Wang, S.M. Ashiqul Islam, Ian Vermes, Stephen Duke, Nithish Bharadhwaj Narasimman, Ting Yang, Zichen Jiang, Sarah Moody, Sergey Senkin, Paul Brennan, Michael R. Stratton and Ludmil B. Alexandrov |
| 4:50-5:10 PM |
A latent variable model for evaluating mutual exclusivity and co-occurrence between driver mutations in cancer (paper) |
Ahmed Shuaibi, Uthsav Chitra and Benjamin Raphael |
| 5:10-5:30 PM |
Refphase: Multi-sample phasing reveals haplotype-specific copy number heterogeneity (highlight) |
Thomas Watkins, Emma Colliver, Matthew Huska, Tom Kaufmann, Emilia Lim, Cody Duncan, Kerstin Haase, Peter Van Loo, Charles Swanton, Nicholas McGranahan and Roland Schwarz |
| 5:30-5:50 PM |
Probing omics data via harmonic persistent homology (paper) |
Davide Gurnari, Aldo Guzmán-Sáenz, Filippo Utro, Aritra Bose, Saugata Basu and Laxmi Parida |