• Alignment and assembly of sequencing reads
• Summarization, comparison and visualization of massive genomics datasets
• Multiple alignment and consensus sequence construction
• Improved methods for calling and characterizing genetic variants including structural variants
• Methods for analysis of RNA sequencing (RNA-seq) data, including single-cell RNA-seq
• Epigenetics and gene regulation, including ChIP-seq analysis, methylation profiling, and histone modification
• Metagenomics
• Methods for analysis of data from other novel sequencing assays
• Translational applications of sequencing data, including cancer genomics and infectious disease
• Pan-genomics, genome graphs, and novel uses of new genome assemblies

We solicit contributions in four categories (“tracks”) as follows:

Proceedings track

Manuscripts describing original work on computational aspects of genomic research involving massively parallel sequencing.  Manuscripts in this track will be considered for publication in a special issue of the journal iScience. At the time of submission, and for the entire review period, the work should not be under review by any other conference or scientific journal. Authors of manuscripts that are selected for oral presentation at RECOMB-Seq after review but are not deemed suitable for iScience (or if the authors do not select publication in iScience) will be required to host their manuscript on a public preprint server. To indicate your submission should be considered for the proceedings track, please include [Proceedings] at the end of the paper title.

Overlay track

Manuscripts submitted to this track will be reviewed by the program committee and selected submissions will be invited for oral presentation. The manuscript should be hosted on a public preprint server (bioRxiv, arXiv or PeerJ) at the time of submission. There are no specific formatting or page length requirements, but the paper should generally be formatted in a way that emphasizes the methodological contributions. Manuscripts can be submitted elsewhere at the same time but should not be published or in press at the time of submission. To indicate your submission should be considered for the overlay track, please include [Overlay] at the end of the paper title.

Highlights Track

This track is for papers that have already been published or are in press. This track is joint with the main conference. For instructions and more details, see HERE.

Abstracts for short talks or posters

Regular abstracts describing original work, including software applications. These will be considered for short oral presentations or posters. A 1-2 page abstract describing the methods and key results should be submitted via the EasyChair system.

All submissions to the proceedings track will be simultaneously considered for publication in a special issue of the journal iScience, if the authors agree. iScience is an open-access journal published by Cell Press for original research in the life, physical, and earth sciences.

In addition to the program committee of RECOMB-seq, editors of iScience will evaluate the papers for biological impact and suitability for publication. In particular, the following criteria will be used to evaluate the biological relevance:

• Can inputs be found through experiments?
• Can outputs be used directly in future experiment or analysis?
• Can outputs be obtained through well-established methodology for less cost?
• Is methodology proposed applicable in useful settings?
• Do biological data support the study?
• Is biological variability sufficiently accounted for?

Authors who do not wish their manuscript to be considered for iScience should use the overlay track for submission. Publication in iScience is subject to an Open Access charge of $3000.

Reduced Open Access charges for authors in developing countries and others in financial hardship are available.

Manuscripts for the “proceedings track” should not exceed 10 pages using at least 11 point font on U.S. standard 8 1/2 by 11 inch paper with no less than one inch margin all around. This excludes the cover page and references. The cover page should have the title and the corresponding author’s email address. An optional short appendix, if absolutely necessary, can be included but will be considered at the discretion of the program committee. Manuscripts must be submitted electronically in PDF format via the EasyChair system.

The submission system will be open starting January 5, 2022 and ending February 11, 2022.

Authors will be notified of acceptance or rejection by email on or before April 1, 2022.  An author of each accepted paper is expected to attend the workshop (if held in person) and present the paper; otherwise, alternative arrangements should be made to have the paper presented.

If you would like to consider submitting a paper rejected by RECOMB 2022 to the workshop, you may do so by the regular deadline of February 11, 2022.

You must include in your submission a Cover Letter that includes the reviews received from RECOMB together with a rebuttal addressing the concerns raised by the reviewers.

The submitted manuscript should also be modified according to the reviews, or provide an explanation of why modifications are unnecessary.

All reviews will be treated confidentially and will only be visible to the PC members.